業績Publication & Awards

2024

Katsube M, Ishimoto T, Fukushima Y, Kagami A, Shuto T, and Kato Y*. Ergothioneine promotes longevity and healthy aging in male mice. GeroScience, in press.

2024

Kurniawan DA, Leo S, Inamatsu M, Funaoka S, Aihara T, Mizuno A, Inoue R, Sakura T, Arakawa H, Kato Y, Matsugi T, Esashika K, Shiraki N, Kume S, Shinha K, Kimura H, Nishikawa M, Sakai Y. Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism. PNAS Nexus 3(2): 070, 2024.　 　※東京大学グループが中心の共同研究

2024

Ishimoto T, Yamashita R, Matsumoto R, Matsumoto S, Matsuo Y, Nakao S, Masuo Y, Suzuki M, Kato Y*. TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans. NPJ Sci Food 8(1): 11, 2024.　※（株）エル・エスコーポレーションとの共同研究

2024

Kimura T, Okada K, Morohashi Y, Kato Y, Mori M, Kato H, Matsumoto T, Shimoyama S. Quantification of unencapsulated drug in target tissues demonstrates pharmacological properties and therapeutic effects of liposomal topotecan (FF-10850). Pharm Res, in press.　※富士フィルム株式会社が中心の共同研究

2024

Scheidecker B, Poulain S, Sugimoto M, Arakawa H, Kim SH, Kawanishi T, Kato Y, Danoy M, Nishikawa M, Sakai Y. Mechanobiological stimulation in organ-on-a-chip systems reduces hepatic drug metabolic capacity in favor of regenerative specialization. Biotechnol Bioeng 121(4): 1435-1452, 2024.　 ※東京大学グループが中心の共同研究

2024

Utami T, Danoy M, Khadim RR, Tokito F, Arakawa H, Kato Y, Kido T, Miyajima A, Nishikawa M, Sakai Y. A highly efficient cell culture method using oxygen-permeable PDMS-based honeycomb microwells produces functional liver organoids from human induced pluripotent stem cell-derived carboxypeptidase M liver progenitor cells. Biotechnol Bioeng 121(4): 1178-1190, 2024.　 　※東京大学グループが中心の共同研究

2024

Imamura R, Sugimoto M, Horike S, Fujita K, Tamai I, Daikoku T, Kato Y, Arakawa H. Role of organic anion transporter NPT4 in renal handling of uremic toxin 3-indoxyl sulfate. J Pharm Sci, in press.Scheidecker B, Poulain S, Sugimoto M, Kido T, Kawanishi T, Miyajima A, Kim SH, Arakawa H, Kato Y, Nishikawa M, Danoy M,Sakai Y, Leclerc E. Dynamic, IPSC-derived Hepatic Tissue Tri-Culture System for the Evaluation of Liver Physiology in vitro. Biofabrication, in press.　※東京大学グループが中心の共同研究

2023

Arakawa H, Kawanishi T, Shengyu D, Nishiuchi T, Meguro-Horike M, Horike S, Sugimoto M, Kato Y. Renal pharmacokinetic adaptation to cholestasis causes increased nephrotoxic drug accumulation by Mrp6 downregulation in mice. J Pharm Sci S0022-3549(23)00327-1. ※慶應義塾大学、金沢大学疾患モデル総合研究センターとの共同研究

2023

 Park AG, Fukasawa K, Horie T, Masuo Y, Inaba Y, Tatsuno T, Yamada T, Tokumura K, Iwahashi S, Iezaki T, Kaneda K, Kato Y, Ishigaki Y, Mieda M, Tanaka T, Ogawa K, Ochi H, Sato S, Shi Y, Inoue H, Lee H, Hinoi E. L-type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis. JCI Insight 8(7): e154925, 2023. ※岐阜薬科大学グループが中心の共同研究 

2023

Alshammaria AH, Masuo Y, Yoshino S, Ymashita R, Ishimoto T, Fujita K, Kato Y. Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice. Drug Metab Pharmacokinet 49:100483, 2023. ※昭和大学との共同研究

2023

Tao F, Hanada S, Matsushima K, Arakawa H, Ishida N, Kato Y, Okimura S, Watanabe T, Kojima N. Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells. J Biosci Bioeng ,135(2): 134-142,2023. ※横浜市立大学グループが中心の共同

2022

Matsumoto T, Masuo Y, Tanaka A, Kimura T, Ioroi T, Yamakawa T, Kitahara H, Kato Y. A physiologically based pharmacokinetic and pharmacodynamic model for disposition of FF-10832.Int J Pharm, 627: 122250, 2022. ※富士フィルム株式会社との共同研究

2022

Danoy M, Scheidecker B, Arakawa H, Esashika K, Ishida N, Ito H, Yanai H, Takahashi J, Nishikawa M, Kato Y, Sakai Y. Cryopreserved human hepatocytes culture optimization on polymethylpentene oxygen permeable membranes for drug screening purposes. Fundam Toxicol Sci 9(4): 135-144, 2022. ※東京大学グループが中心の共同研究

2022

Katsube M, Watanabe H, Suzuki K, Ishimoto T, Tatebayashi Y, Kato Y, Murayama N. Food-derived antioxidant ergothioneine improves sleep difficulties in humans. J Functional Foods 95: 105165, 2022. サントリーグローバルイノベーションセンターが中心の共同研究

2022

Nishikawa M, Ito H, Tokito F, Hirono K, Inamura K, Scheidecker B, Danoy M, Kawanishi T, Arakawa H, Kato Y, Esashika K, Miyasako H, Sakai Y. Accurate evaluation of hepatocyte metabolisms on a noble oxygen-permeable material with low sorption characteristics. Front Toxicol 4: 810478, 2022. ※東京大学グループが中心の共同研究

2022

 Alshammari AH, Masuo Y, Fujita K, Iida N, Shimada K, Wakayama T, Kato Y*. Discrimination of hand-foot skin reaction of tyrosine kinase inhibitors based on direct keratinocytes toxicity and vascular endothelial growth factor receptor-2 inhibition. Biochem Pharmacol 197: 114914, 2022. 昭和大学、熊本大学との共同研究

2021

Matsukawa T, Mizutani S, Matsumoto K, Kato Y, Yoshihara M, Shibata K, Kajiyama H. Placental leucine aminopeptidase as a potential specific urine biomarker for invasive ovarian cancer. J Clin Med 11(1), 222, 2021. ※名古屋大学グループが中心の共同研究

2021

 Danoy M, Tauran Y, Poulain S, Jellali R, Bruce J, Leduc M, Le Gall M, Koui Y, Arakawa H, Gilard F, Gakiere B, Kato Y, Plessy C, Kido T, Miyajima A, Sakai Y, Leclerc E. Investigation of the hepatic development in the coculture of hiPSCs-derived LSECs and HLCs in a fluidic microenvironment. APL Bioeng 5(2): 026104, 2021. ※東京大学グループが中心の共同研究

2021

 Makiishi S, Furuichi K, Yamamura Y, Sako K, Shinozaki Y, Toyama T, Kitajima S, Iwata Y, Sakai N, Shimizu M, Hirose-Sugiura T, Kaneko S, Kato Y, Wada T. Carnitine/organic cation transporter 1 precipitates the progression of interstitial fibrosis through oxidative stress in diabetic nephropathy in mice. Sci Rep 11(1):9093, 2021. ※金沢大学医学系グループが中心の共同研究

2021

Iida N, Yamashita T, Yutani M, Seishima J, Wang Z, Arai K, Okada H, Yamashita T, Sakai Y, Masuo Y, Agustina R, Kato Y, Fujinaga Y, Oshima M, Honda M, Lebreton F, Gilmore MS, Kaneko S. Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis. Nat Cancer 2(10): 1039-1054, 2021. ※金沢大学医学系グループが中心の共同研究

2021

 de Heredia ML, Muñoz L, Carru C, Sotgia S, Zinellu A, Serra C, Llebaria A, Kato Y, Nunes V. S-methyl-L-ergothioneine to L-ergothioneine ratio in urine is a marker of cystine lithiasis in a cystinuria mouse model. Antioxidants 10(9): 1424, 2021. ※IDIBELL (Spain)グループが中心の共同研究

2021

 Shinha K, Nihei W, Nakamura H, Goto T, Kawanishi T, Ishida N, Yamazaki N, Imakura Y, Mima S, Inamura K, Arakawa H, Nishikawa M, Kato Y, Sakai Y, Kimura H. A kinetic-pump integrated microfluidic plate (KIM-Plate) with high usability for cell culture-based multi-organ microphysiological systems. Micromachines 12(9): 1007, 2021. ※東海大学グループが中心の共同研究

2021

 Agustina R, Masuo Y, Kido Y, Shinoda K, Ishimoto T, Kato Y*. Identification of food-derived isoflavone sulfates as inhibition markers for intestinal breast cancer resistance proteins. Drug Metab Dispos, 49(11): 972-984, 2021. ※塩野義製薬株式会社との共同研究

2021

Danoy M, Tauran Y, Poulain S, Jellali R, Bruce J, Leduc M, Gall ML, Gilard F, Kido T, Arakawa H, Araya K, Mori D, Kato Y, Kusuhara H, Plessy C, Miyajima A, Sakai Y, Leclerc E. Multi-omics analysis of hiPSCs-derived HLCs matured on-chip revealed patterns typical of liver regeneration. Biotechnol Bioeng 118(10): 3716-3732, 2021. ※東京大学グループが中心の共同研究

2021

Sako K, Nakamaru Y, Ikawa K, Maeda T, Goto S, Ishihara Y, Kato Y, Matsuda Y. Population Pharmacokinetics and dosing optimization of teicoplanin in neutropenic patients with hematological malignancies. Ther Drug Monit 43(4): 519-526, 2021. ※日本薬科大学グループが中心の共同研究

2021

 Matsumoto T, Komori T, Yoshino Y, Ioroi T, Kitahashi T, Kitahara H, Ono K, Higuchi T, Sakabe M, Kori H, Kano M, Hori R, Kato Y, Hagiwara S. A liposomal gemcitabine, FF-10832, improves plasma stability, tumor targeting, and antitumor efficacy of gemcitabine in pancreatic cancer xenograft models. Pharm Res 38(6): 1093-1106, 2021. ※富士フィルム株式会社が中心の共同研究

2021

Shinohara M, Arakawa H, Oda Y, Shiraki N, Sugiura S, Nishiuchi T, Satoh T, Iino K, Leo S, Kato Y, Araya K, Kawanishi T, Nakatsuji T, Mitsuta M, Inamura K, Goto T, Shinha K, Nihei W, Komori K, Nishikawa M, Kume S, Kato Y, Kanamori T, Sakai Y, Kimura H. Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system. Sci Rep 11(1): 5437, 2021. ※東海大学グループが中心の共同研究

2021

Nakamichi N, Nakao S, Nishiyama M, Takeda Y, Ishimoto T, Masuo Y, Matsumoto A, Suzuki M, and Kato Y. Oral administration of the food derived hydrophilic antioxidant ergothioneine enhances object recognition memory in mice. Curr Mol Pharmacol 14(2):220-233, 2021. ※株式会社 エル・エス コーポレーションとの共同研究

2021

Futatsugi A, Masuo Y, Kato Y. Effects of Probenecid on Hepatic and Renal Disposition of Hexadecanedioate, an Endogenous Substrate of Organic Anion Transporting Polypeptide 1B in Rats. J Pharm Sci 110(5): 2274-2284, 2021.

2020

Masuo Y, Fujita K, Mishiro K, Seba N, Kogi T, Okumura H, Matsumoto N, Kunishima M, and KATO Y. 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients. Drug Metab Pharmacokinet 35(6): 555-562, 2020.  ※昭和大学との共同研究

2020

Nishiyama M, Nakamichi N, Yoshimura T, Masuo Y, Komori T, Ishimoto T, Matsuo JI, Kato Y. Homostachydrine is a xenobiotic substrate of OCTN1/SLC22A4 and potentially sensitizes pentylenetetrazole-induced seizures in mice. Neurochem Res 45(11):2664-2678, 2020.

2020

Taguchi T, Masuo Y, Futatsugi A, Kato Y. Static model-based assessment of OATP1B1-mediated drug interactions with preincubation-dependent inhibitors based on inactivation and recovery kinetics. Drug Metab Dispos 48(9): 750-758, 2020.

2020

渡邉憲和、松本 聡、鈴木 真、深谷泰亮、加藤将夫、橋弥尚孝　健常者および軽度認知障害者に対するエルゴチオネイン含有食品の認知機能改善効果 ランダム化プラセボ対照二重盲検並行群間比較試験、薬理と治療 48(4): 685-697, 2020.

2020

Sarashina A, Chiba K, Tatami S, Kato Y. Physiologically based pharmacokinetic model of the DPP-4 inhibitor linagliptin to describe its nonlinear pharmacokinetics in humans. J Pharm Sci 109(7): 2336-2344, 2020. ※日本ベーリンガーインゲルハイムとの共同研究

2020

Kubota Y, Fujita K, Takahashi T, Sunakawa Y, Ishida H, Hamada K, Ichikawa W, Tsunoda T, Shimada K, Masuo Y, Kato Y, and Sasaki Y. Higher systemic exposure to unbound active metabolites of regorafenib is associated with short progression-free survival in colorectal cancer patients. Clin Pharmacol Ther 108(3): 586-595, 2020. ※昭和大学グループが中心の共同研究

2020

Arakawa H, Sugiura S, Kawanishi T, Shin K, Toyoda H, Satoh T, Sakai Y, Kanamori T, Kato Y. Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system. Lab on a Chip 20(3): 537-547, 2020. ※産業技術総合研究所、東京大学との共同研究

2020

Takahashi Y, Zhou Y, Miyamoto T, Higashi H, Nakamichi N, Takeda Y, Kato Y, Korchev Y, Fukuma T. High-speed SICM for the visualization of nanoscale dynamic structural changes in hippocampal neurons. Anal Chem 92(2):2159-2167, 2020. ※金沢大学WPI-NanoLSIグループが中心の共同研究

2019

Hashimoto N, Nakamichi N, Nanmo H, Kimura K, Masuo Y, Sakai Y, Schinkel AH, Sato S, Soga T, Kato Y. Metabolome analysis reveals dermal histamine accumulation in murine dermatitis provoked by genetic deletion of P-glycoprotein and breast cancer resistance protein. Pharm Res 36(11): 158, 2019. ※マルホ株式会社、東京大学、慶應義塾大学、The Netherlands Cancer Institute (オランダ)との共同研究

2019

Taguchi T, Masuo Y, Sakai Y, Kato Y. Short-lasting inhibition of hepatic uptake transporter OATP1B1 by tyrosine kinase inhibitor pazopanib. Drug Metab Pharmacokinet 34(6):372-379, 2019.

2019

Nakamichi N, Matsumoto Y, Kawanishi T, Ishimoto T, Masuo Y, Horikawa M, Kato Y. Maturational characterization of mouse cortical neurons three-dimensionally cultured in functional polymer FP001-containing medium. Biol Pharm Bull 42(9): 1545-1553, 2019. ※日産化学株式会社との共同研究

2019

Kawanishi T, Arakawa H, Masuo Y, Nakamichi N, Kato Y. Bile duct obstruction leads to increased intestinal expression of breast cancer resistance protein with reduced gastrointestinal absorption of imatinib. J Pharm Sci 108(9): 3130-3137, 2019.

2019

Al-Shammari AH, Masuo Y, Fujita K, Yoshikawa Y, Nakamichi N, Kubota Y, Sasaki Y, Kato Y. Influx and efflux transporters contribute to the increased dermal exposure to active metabolite of regorafenib after repeated oral administration. J Pharm Sci 108(6): 2173-2179, 2019. ※昭和大学との共同研究

2019

Hydrolyzed salmon milt extract enhances object recognition and location memory through an increase in hippocampal cytidine nucleoside levels in normal mice. Nakamichi N, Nakao S, Masuo Y, Koike A, Matsumura N, Nishiyama M, Al-Shammari AH, Sekiguchi H, Sutoh K, Usumi K, Kato Y. J Med Food 22(4): 408-415, 2019. ※フォーデイズ株式会社との共同研究

2019

Ishimoto T, Masuo Y, Kato Y, and Nakamichi N. Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells. Cellular Signalling 53: 269-280, 2019.

2018

Masuo Y, Ohba Y, Yamada K, Al-Shammari AH, Seba N, Nakamichi N, Ogihara T, Kunishima M, Kato Y. Combination metabolomics approach for identifying endogenous substrates of carnitine/organic cation transporter OCTN1. Pharm Res 35(11): 224, 2018. ※高橋健康福祉大学との共同研究

2018

Futatsugi A, Toshimoto K, Yoshikado T, Sugiyama Y, Kato Y. Evaluation of alteration in hepatic and intestinal BCRP function in vivo due to ABCG2 c.421C>A polymorphism based on PBPK analysis of rosuvastatin. Drug Metab Dispos 46(5): 749-757, 2018. ※理化学研究所との共同研究

2018

Ellawatty WEA, Masuo Y, Fujita KI, Yamazaki E, Ishida H, Arakawa H, Nakamichi N, Abdelwahed R, Sasaki Y, Kato Y. Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib. Drug Metab Dispos 46(1): 33-40, 2018. ※昭和大学、Alexandria University (エジプト)との共同研究

2018

Ishimoto T, Nakamichi N, Nishijima H, Masuo Y, Kato Y. Carnitine/organic cation transporter OCTN1 negatively regulates activation in murine cultured microglial cells. Neurochem Res 43(1): 107-119, 2018.

2018

Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies. Hashimoto S, Honda K, Fujita K, Miyachi Y, Isoda K, Misaka K, Suga Y, Kato S, Tsuchiya H, Kato Y, Okajima M, Taniguchi T, Shimada T, Sai Y. J Pharm Health Care Sci 4: 27, 2018. ※金沢大学附属病院薬剤部が中心の共同研究

2018

Tashiro Y, Sakai R, Hirose-Sugiura T, Kato Y, Matsuo H, Takada T, Suzuki H, Makino T. Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter. Molecules 23(11), 2018. ※名古屋市立大学グループが中心の共同研究

2017

Fujita K, Masuo Y, Yamazaki E, Shibutani T, Kubota Y, Nakamichi N, Sasaki Y, Kato Y. Involvement of the transporters P-gp and BCRP in dermal distribution of the multi-kinase inhibitor regorafenib and its active metabolites. J Pharm Sci 106(9): 2632-2641, 2017. ※昭和大学との共同研究

2017

Masuo Y, Nagamori S, Hasegawa A, Hayashi K, Isozumi N, Nakamichi N, Kanai Y, Kato Y. Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans. Pharm Res 34(6): 1233-1243, 2017. ※大阪大学との共同研究

2017

Hashimoto N, Nakamichi N, Yamazaki E, Oikawa M, Masuo Y, Schinkel AH, Kato Y. P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids. Int J Pharm 521(1-2): 365-373, 2017. ※マルホ株式会社、The Netherland Cancer Institute (オランダ)との共同研究

2017

Shinozaki Y, Furuichi K, Toyama T, Kitajima S, Hara A, Iwata Y, Sakai N, Shimizu M, Kaneko S, Isozumi N, Nagamori S, Kanai Y, Sugiura T, Kato Y, Wada T. Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease. Kid Int 92(6): 1356-1369, 2017. ※金沢大学医学系グループが中心の共同研究

2016

Nakamichi N, Ishimoto T, Yamauchi Y, Masuo Y, Kato Y. Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity. Biol Pharm Bull 39(10): 1638-1645, 2016.

2016

Futatsugi A, Masuo Y, Kawabata S, Nakamichi N, Kato Y. L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides. J Pharm Pharmaco 68(9): 1160-1169, 2016.

2016

Taguchi T, Masuo Y, Kogi T, Nakamichi N, Kato Y. Characterization of long-lasting Oatp inhibition by typical inhibitor cyclosporine A and in vitro-in vivo discrepancy in its drug interaction potential in rats. J Pharm Sci 105(7):2231-2239, 2016.

2016

Nakamichi N, Nakayama K, Ishimoto T, Masuo Y, Wakayama T, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kato Y. Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice. Brain and Behavior e00477, 2016. ※株式会社 エル・エス コーポレーションとの共同研究

2016

Tang Y, Masuo Y, Sakai Y, Wakayama T, Sugiura T, Harada R, Futatsugi A, Komura T, Nakamichi N, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kaneko S, Kato Y. Localizatoin of xenobiotic transporter OCTN1/SLC22A4 in hepatic stellate cells and its protective role in liver fibrosis. J Pharm Sci 105(5): 1779-1789, 2016. ※株式会社 エル・エス コーポレーション、金沢大学医学系との共同研究

2016

Fujita K, Masuo Y, Okumura H, Watanabe Y, Suzuki H, Sunakawa Y, Shimada K, Kawara K, Akiyama Y, Kitamura M, Kunishima M, Sasaki Y, Kato Y. Increased plasma concentrations of unbound SN-38, the active metabolite of irinotecan, in cancer patients with severe renal failure. Pharm Res 33(2): 269-282, 2016. ※昭和大学との共同研究

2016

Abouzed TK, Munesue S, Harashima A, Masuo Y, Kato Y, Kahilo KKK, Yamamoto H, Yamamoto Y. Preventive effect of salicylate and pyridoxamine on diabetic nephropathy. J Diabetes Res 2016: Article ID 1786789, 2016. ※金沢大学医学系グループが中心の共同研究

2016

A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60. Human Genetics 135(5): 513-524, 2016.

2016

Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Kato Y, Oriuchi N, Nagamori S, Kanai Y. Transport of 3-fluoro-L-alpha-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [18F]FAMT positron emission tomography. J Pharmacol Sci 130(2): 101-199, 2016. ※大阪大学グループが中心の共同研究

2016

Yamada T, Takakura H, Jue T, Hashimoto T, Ishizawa R, Furuichi Y, Kato Y, Iwanaka N, Masuda K. Myoglobin and the regulation of mitochondrial respiratory chain complex IV. J Physiol 594(2): 483-495, 2016. ※金沢大学人文社会研究域グループが中心の共同研究

2016

Matsuo H, Yamamoto K, Nakaoka H, Nakayama A, Sakiyama M, Chiba T, Takahashi A, Nakamura T, Nakashima H, Takada Y, Danjoh I, Shimizu S, Abe J, Kawamura Y, Terashige S, Ogata H, Tatsukawa S, Yin G, Okada R, Morita E, Naito M, Tokumasu A, Onoue H, Iwaya K, Ito T, Takada T, Inoue K, Kato Y, Nakamura Y, Sakurai Y, Suzuki H, Kanai Y, Hosoya T, Hamajima N, Inoue I, Kubo M, Ichida K, Ooyama H, Shimizu T, Shinomiya N. Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann Rheum Dis 75(4): 652-659, 2016. ※防衛医科大学校グループが中心の共同研究

2015

Shimizu T, Kijima A, Masuo Y, Ishimoto T, Sugiura T, Takahashi S, Nakamichi N, Kato Y. Gene ablation of carnitine/organic cation transporter 1 reduces gastrointestinal absorption of 5-aminosalicylate in mice. Chem Pharm Bull 38(5): 774-780, 2015.

2015

Shimizu T, Masuo Y, Takahashi S, Nakamichi N and Kato Y. Organic Cation Transporter Octn1-mediated Uptake of Food-derived Antioxidant Ergothioneine into Infiltrating Macrophages during Intestinal Inflammation in Mice. Drug Metab Pharmacokinet 30(3): 231-239, 2015.

2015

Naka K, Jomen Y, Ishihara K, Kim J, Ishimoto T, Bae E, Mohney R, Stirdivant SM, Oshima H, Oshima M, Kim DW, Nakauchi H, Takihara Y, Kato Y, Ooshima A, Kim SJ. Dipeptide species regulate nutrient signalling essential for the maintenance of chronic myelogenous leukaemia stem cells. Nature Commun 6: 8039, 2015. ※金沢大学がん進展制御研究所グループが中心の共同研究

2014

Ishimoto T, Nakamichi N, Hosotani H, Masuo Y, Sugiura T, Kato Y. Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons. PLoS One 9: e89434, 2014.

2014

Takeuchi K, Sugiura T, Matsubara K, Sato R, Shimizu T, Masuo Y, Horikawa M, Nakamichi N, Ishiwata N and Kato Y. Interaction of novel platelet-increasing agent eltrombopag with rosuvastatin via breast cancer resistance protein in human. Drug Metab Dispos 42: 726-734, 2014. ※日産化学株式会社との共同研究

2014

Fujita K, Sugiura T, Okumura H, Umeda S, Nakamichi N, Watanabe Y, Suzuki H, Sunakawa Y, Shimada K, Kawara K, Sasaki Y and Kato Y. Direct inhibition and down-regulation by uremic plasma components of hepatic uptake transporter for SN-38, an active metabolite of irinotecan, in humans. Pharm Res31: 204-215, 2014. ※昭和大学との共同研究

2014

Kawase A, Sakata M, Yada N, Nakasaka M, Shimizu T, Kato Y, Iwaki M. Decreased radixin function for ABC transporters in liver in adjuvant-induced arthritis rats. J Pharm Sci 103(12): 4058-4065, 2014. ※近畿大学グループが中心の共同研究

2014

Kawase A, Norikane S, Okada A, Adachi M, Kato Y, Iwaki M. Distinct Alterations in ABC Transporter Expression in Liver, Kidney, Small Intestine, and Brain in Adjuvant-induced Arthritic Rats. J Pharm Sci 103: 2556-2564, 2014. 近畿大学グループが中心の共同研究

2014

Adachi E, Hirose-Sugiura T, Kato Y, Ikebuchi F, Yamashita A, Abe T, Fukuta K, Adachi K and Matsumoto K. Pharmacokinetics and pharmacodynamics following intravenous administration of recombinant human hepatocyte growth factor in rats with renal injury. Pharmacology 94(3-4): 190-187, 2014. ※金沢大学がん進展制御研究所グループが中心の共同研究

2013

Nakamichi N, Shima H, Asano S, Ishimoto T, Sugiura T, Matsubara K, Kusuhara H, Sugiyama Y, Sai Y, Miyamoto K, Tsuji A and Kato Y. Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. J Pharm Sci 102: 3407-3417, 2013. ※金沢大学附属病院薬剤部、東京大学との共同研究

2013

Hashimoto N, Nakamichi N, Uwafuji S, Yoshida K, Sugiura T, Tsuji A, Kato Y. ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate. J Control Rel 165(1): 54-61, 2013. ※マルホ株式会社との共同研究

2013

Sugiura T, Takahashi S, Sano K, Abe T, Fukuta K, Adachi K, Nakamura T, Matsumoto K, Nakamichi N, Kato Y. Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans. J Pharm Sci 102(1): 237-249, 2013. ※クリングルファーマ株式会社、金沢大学がん進展制御研究所、大阪大学との共同研究

2013

Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T. Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria. Toxicol Sci 132(1): 32-42, 2013. ※千葉大学グループが中心の共同研究

2012

Nakamichi N, Taguchi T, Hosotani H, Wakayama T, Shimizu T, Sugiura T, Iseki S, Kato Y. Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation. Neurochem Int 61(7): 1121-1132, 2012. ※金沢大学医学系との共同研究

2012

Furuichi Y, Sugiura T, Kato Y, Takakura H, Hanai Y, Hashimoto T, Masuda K. Muscle contraction increases carnitine uptake via translocation of OCTN2. Biochem Biophys Res Commun 418(4): 774-779, 2012. ※金沢大学人文社会研究域グループが中心の共同研究

2011

Takeuchi K, Sugiura T, Umeda S, Matsubara K, Horikawa M, Nakamichi N, Silver DL, Ishiwata N, Kato Y. Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-Increasing agent. Drug Metab Dispos 39(6): 1088-1096, 2011. ※日産化学株式会社、Albert Einstein College of Medicine (USA)との共同研究

2011

Kano T, Wada S, Morimoto K, Kato Y, Ogihara T. Effect of knockdown of ezrin, radixin and moesin on P-glycoprotein function in HepG2 cells. J Pharm Sci 100(9): 3620-3635, 2011. ※高崎健康福祉大学グループが中心の共同研究

2010

Sugiura T, Otake T, Shimizu T, Wakayama T, Silver DL, Utsumi R, Nishimura T, Iseki S, Nakamichi N, Kubo Y, Tsuji A, Kato Y. PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine. Drug Metab Pharmacokinet 25(5): 588-598, 2010.

2010

Sugiura T, Kato S, Shimizu T, Wakayama T, Nakamichi N, Kubo Y, Iwata D, Suzuki K, Soga T, Asano M, Iseki S, Tamai I, Tsuji A, Kato Y. Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver. Drug Metab Dispos 38(10): 1665-1672, 2010.

2010

Meng Q, Liu Q, Wang C, Sun H, Kaku T, Kato Y, Liu K. Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters. Drug Metab Pharmacokinet 25(4): 320-327, 2010. ※大連医科大学グループが中心の共同研究

2010

Furuichi Y, Sugiura T, Kato Y, Shimada Y, Masuda K. OCTN2 is associated with carnitine transport capacity of rat skeletal muscles. Acta Physiologica 200(1): 57-64, 2010. ※金沢大学人文社会研究域グループが中心の共同研究